These products are prescribed to treat severe cases of acne that are difficult to treat any other way. Estrogen-containing products can cause or worsen the symptoms of angioedema.Some of the most serious health effects come from isotretinoin products, such as Accutane® or Clarus® that are derived from vitamin A.
if you have hereditary angioedema: Consult your doctor immediately if you experience any of the symptoms of angioedema such as swelling of the face, tongue or throat and / or difficulty swallowing, or rash accompanied by difficulty breathing. In such cases, avoid overexposure to the sun or ultraviolet rays if you have (or have ever had) golden brown pigment spots on your skin, so-called "pregnancy spots", especially on the face (chloasma). 
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if you have a condition that first appeared or worsened in pregnancy or previous use of sex hormones (such as hearing loss, metabolism called porphyria, skin disease called gestational herpes, neurological disease called chorea in Sydney). you have hemolytic uremic syndrome (HUS: impaired blood clotting leading to acute renal failure). if you suffer from systemic lupus erythematosus (CJIE: a disease affecting the skin of the whole body). if you suffer from Crohn's disease or ulcerative colitis (chronic inflammatory bowel disease). if you have liver or gallbladder disease. if one of your family has suffered from breast cancer. if you or one of your family has or has high levels of cholesterol or triglycerides (fatty substances) in the blood. if any of your family members had blood clots (thrombosis in the leg, lung “pulmonary embolism” or somewhere else), heart attack or stroke at a young age. if you suffer from vein inflammation (superficial phlebitis). if you have heart valve damage or rhythm disorders. In addition, if any of these conditions occur or worsen when you use Diane 35, you should inform your doctor: If any of the following conditions apply to you, you should consult your doctor before using Diane 35. In some situations, you must take special care when using Diane 35 or another combination hormonal contraceptive, and you may need to be examined regularly by your doctor. This may cause, for example, itching, rashes and swelling. if you are allergic (hypersensitive) to ethinylestradiol or cyproterone acetate or to any of the other ingredients of Diane 35. if you are pregnant or think you may be pregnant. if you get vaginal bleeding of unclear origin. if you have (or have ever had) a benign or malignant liver tumor. if you have (or have ever had) cancer that can grow under the influence of sex hormones (such as breasts or genitals). 
if you have (or have ever had) a liver disease (symptoms that may be yellowing of the skin or itching throughout the body) and your liver is still not working properly.if you have (or have ever had) a migraine with visual impairments.if you have problems with your blood clotting (eg protein C deficiency).
O very high level of fatty substances in your blood (cholesterol or triglycerides) This applies to the following conditions: if you have a condition that may increase the risk of blood clotting in the arteries.if you have (or have had) ever) heart attack or stroke.if you have (or have ever had) a condition that may be indicative of a future heart attack (eg angina pectoris causing severe chest pain) or a mini-stroke (transient ischemic attack).if you have (or have ever had a blood clot in the leg (thrombosis), lungs (pulmonary embolism), or other parts of the body.if you use another hormonal contraceptive.Tell your doctor if any of the following applies to you before you start using Diane 35: Your doctor may then advise you to use another treatment:
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